Basic Information
| LncRNA/CircRNA Name | circ_0021093 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Dual luciferase reporter gene assay , cell growth detection , cell apoptosis determination , wound scratch test, transwell experiment , immunoblotting assay |
| Sample | HCC tissues and nontumor tissues ,HCC cell lines (Sk-Hep-1, SMMC7721, HCCLM3, Huh-7 and HepG2) and L02 cell line |
| Expression Pattern | up-regulated |
| Function Description | Upregulation of circ_0021093 was found in HCC tumor samples and cells. Additionally, upregulated circ_0021093 was related to adverse clinical characteristics and an unfavorable prognosis. Furthermore, downregulated circ_0021093 attenuated cell growth, migration and invasion but increased cell apoptosis.By contrast, ectopically expressed circ_0021093 enhanced the abovementioned malignant biological behaviors. circ_0021093 sponges of miR-766-3p were used in HCC cells. In addition,metastasis-associated protein 3 (MTA3) was a direct target of miR-766-3p and that the oncogenic function of circ_0021093 was partly dependent on the miR-766-3p/MTA3 axis . |
| Pubmed ID | 31330234 |
| Year | 2019 |
| Title | Overexpression of circ_0021093 Circular RNA Forecasts an Unfavorable Prognosis and Facilitates Cell Progression by Targeting the miR-766-3p/MTA3 Pathway in Hepatocellular Carcinoma |
External Links
| Links for circ_0021093 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |