Basic Information
| LncRNA/CircRNA Name | circ_0007059 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blotting , cell apoptosis assay |
| Sample | lung cancer tissues and the adjacent non -tumor tissues ,lung cancer cell lines(A549 and H1975) |
| Expression Pattern | up-regulated |
| Function Description | Inhibition of hsa_circ_0007059 was discovered in lung cancer tissues. Overexpressed hsa_circ_0007059 evidently restrained cell proliferation, elevated p53 and repressed CyclinD1 expression, meanwhile triggered apoptosis and enhanced Bax and Cleaved-Caspase-3 expression.Increased hsa_circ_0007059 abated EMT via enhancement of E-cadherin and inhibition of Vimentin, Twist and Zeb1 in A549 and H1975 cells. MiR-378 was up-regulated in lung cancer tissues, declined by hsa_circ_0007059 overexpression in A549 and H1975 cells. Overexpressed hsa_circ_0007059 hindered Wnt/?-catenin and ERK1/2 pathways via suppressing miR-378 in A549 and H1975 cells. |
| Pubmed ID | 31351967 |
| Year | 2019 |
| Title | Circular RNA hsa_circ_0007059 Restrains Proliferation and Epithelial-Mesenchymal Transition in Lung Cancer Cells via Inhibiting microRNA-378 |
External Links
| Links for circ_0007059 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |