Basic Information
| LncRNA/CircRNA Name | circ_9119 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bone cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blotting , luciferase reporter assay , Macroarray |
| Sample | malignant mice spinal cord tissues ,sarcoma cells |
| Expression Pattern | down-regulated |
| Function Description | circ9119 expression was repressed in the spinal cord of bone malignancy pain model mice.Overexpression of circ9119 by plasmid injection in the model mice reduced progressive thermal hyperalgesia and mechanical hyperalgesia. circ9119 functions as a sponge of miR-26a, which targets the TLR3 3'-untranslated region. Furthermore, expression of miR-26a was elevated and TLR3 level was repressed in bone malignancy pain model mice, which were counteracted by circ9119 in the spinal cord of tumor-bearing mice. Moreover, excessive expression of miR-26a was involved in the recovery of mice from progressive thermal hyperalgesia and mechanical hyperalgesia triggered via circ9119. TLR3 knockdown in bone malignancy pain model mice thoroughly impaired pain in the initial stages and reduced the effects of circ9119 on hyperalgesia. |
| Pubmed ID | 31368062 |
| Year | 2019 |
| Title | Spinal circRNA-9119 Suppresses Nociception by Mediating the miR-26a-TLR3 Axis in a Bone Cancer Pain Mouse Model |
External Links
| Links for circ_9119 | GenBank HGNC NONCODE |
| Links for bone cancer | OMIM COSMIC |