Basic Information
| LncRNA/CircRNA Name | circHECTD1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR |
| Sample | gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | we showed that circHECTD1 expression was markedly upregulated in gastric cancer (GC) and was associated with lymph node metastasis and American Joint Committee on Cancer stage. The circHECTD1 expression level was found to be an independent prognostic factor for GC patients. circHECTD1 knockdown inhibited GC cell glutaminolysis, proliferation, migration, and invasion, whereas circHECTD1 overexpression promoted GC progression. |
| Pubmed ID | 31371702 |
| Year | 2019 |
| Title | circHECTD1 Facilitates Glutaminolysis to Promote Gastric Cancer Progression by Targeting miR-1256 and Activating ?-catenin/c-Myc Signaling |
External Links
| Links for circHECTD1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |