Basic Information
| LncRNA/CircRNA Name | circPAN3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Acute Myeloid Leukemia |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | Acute Myeloid Leukemia cell lines and blood |
| Expression Pattern | down-regulated |
| Function Description | downregulation of circPAN3 by small interfering RNA (siRNA) significantly restored drug sensitivity to ADM in the two ADM-resistant cell lines, but lentivirus-mediated circPAN3 overexpression had the opposite effect. circPAN3 may facilitate AML drug resistance through regulating autophagy and influencing expression of apoptosis-related proteins, while AMPK/mTOR signaling plays a key role in the regulation of circPAN3 on autophagy. |
| Pubmed ID | 31401408 |
| Year | 2019 |
| Title | CircPAN3 Contributes to Drug Resistance in Acute Myeloid Leukemia Through Regulation of Autophagy |
External Links
| Links for circPAN3 | GenBank HGNC NONCODE |
| Links for Acute Myeloid Leukemia | OMIM COSMIC |