Basic Information
| LncRNA/CircRNA Name | circCDC45 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, luciferase reporter and rescue assays |
| Sample | glioma tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | High circ-CDC45 expression was found in GM specimens and cells, which was tightly related to a larger tumor size, higher world health organization (WHO) stages, and worse survival for patients with GM. Functionally, manipulation of circ-CDC45 expression strongly affected cell growth, apoptosis, migration and invasion, which suggests the oncogenic function of circ-CDC45 in GM oncogenesis. |
| Pubmed ID | 31407396 |
| Year | 2019 |
| Title | Overexpression of Circular RNA circ-CDC45 Facilitates Glioma Cell Progression by Sponging miR-516b and miR-527 and Predicts an Adverse Prognosis |
External Links
| Links for circCDC45 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |