Basic Information
| LncRNA/CircRNA Name | circ_102958 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, western blot, CCK8 and colony formation assay |
| Sample | colorectal cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | we found that hsa_circRNA_102958 expression was significantly increased in CRC tissues, compared to adjacent normal controls. Increased hsa_circRNA_102958 levels in CRC patients indicated a poor prognosis. The effects of hsa_circRNA_102958 on CRC cell proliferation, migration and invasion were then determined by CCK8, colony formation and Transwell assays. We showed that hsa_circRNA_102958 silencing markedly suppressed CRC growth, migration and invasion. |
| Pubmed ID | 31413634 |
| Year | 2019 |
| Title | Circular RNA hsa_circRNA_102958 Promotes Tumorigenesis of Colorectal Cancer via miR-585/CDC25B Axis |
External Links
| Links for circ_102958 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |