Basic Information
| LncRNA/CircRNA Name | circ_100395 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, western blot, CCK-8, flow cytometry, Transwell assay |
| Sample | liver cancer tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | We found that circ_100395 was downregulated in cancerous liver tissues relative to the adjacent normal tissues. The overexpression of circ_100395 was negatively associated with tumor differentiation, microvascular invasion, and portal vein tumor thrombosis. However, patients with higher circ_10039 expression tended to have better postoperative disease-free survival time. Moreover, upregulation of circ_100395 in liver cancer cells inhibited cell proliferation, induced apoptosis, then silenced the EMT pathway and reduced migration and invasion abilities, while this anti-tumor effect was significantly reversed by the downstream target, miR-1228. |
| Pubmed ID | 31421050 |
| Year | 2019 |
| Title | Role of CircRNAs_100395 in Proliferation and Metastases of Liver Cancer |
External Links
| Links for circ_100395 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |