Basic Information
| LncRNA/CircRNA Name | CCAL |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | cell line (Huh7, HCCLM3,LO2), HCC tissues |
| Expression Pattern | up-regulated |
| Function Description | Higher expression of CCAL was found in HCC tumor tissues compared with normal tissues, and was associated with tumor metastasis and TNM stage. Furthermore, the decreased histone H3 methylation and increased histone H3 acetylation across CCAL promoter region contributed to the upregulation of CCAL in HCC. Moreover, the depletion of CCAL inhibited HCC cellular invasion and proliferation, and promoted cell apoptosis. In addition, CCAL depletion up-regulated AP-2a expression and inhibited Wnt/B-catenin pathway activation. |
| Pubmed ID | 29275200 |
| Year | 2018 |
| Title | Long non-coding RNA CCAL promotes hepatocellular carcinoma progression by regulating AP-2a and Wnt/B-catenin pathway. |
External Links
| Links for CCAL | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |