Basic Information
| LncRNA/CircRNA Name | circLMNB1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, CCK-8, assay, Edu assay, flow cytometry, Hoechst staining, and the Transwell assay |
| Sample | colorectal cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | CircLMNB1 expression was significantly upregulated in CRC tissues and cells. Knockdown of circLMNB1 by siRNA in LoVo cells suppressed cell proliferation, migration and invasion, and facilitated cell cycle arrest and apoptosis |
| Pubmed ID | 31496737 |
| Year | 2019 |
| Title | CircLMNB1 Promotes Colorectal Cancer by Regulating Cell Proliferation, Apoptosis and Epithelial-Mesenchymal Transition |
External Links
| Links for circLMNB1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |