Basic Information
| LncRNA/CircRNA Name | circ_0000284 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | exosome | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cholangiocarcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Dual luciferase reporter assay, RNA binding protein immunoprecipitation (RIP) assay |
| Sample | cholangiocarcinoma cell lines, tissues and plasma exosomes |
| Expression Pattern | up-regulated |
| Function Description | Circ-0000284 was evidently elevated in cholangiocarcinoma cell lines, tumor tissues and plasma exosomes. Meanwhile, the high expression of circ-0000284 enhanced the migration, invasion and proliferation abilities of cholangiocarcinoma cells in vivo and in vitro Besides, the levels of circ-0000284 were increased in cholangiocarcinoma cells and exosomes from them. |
| Pubmed ID | 31501232 |
| Year | 2019 |
| Title | Circ-0000284 Arouses Malignant Phenotype of Cholangiocarcinoma Cells and Regulates the Biological Functions of Peripheral Cells Through Cellular Communication |
External Links
| Links for circ_0000284 | GenBank HGNC NONCODE |
| Links for cholangiocarcinoma | OMIM COSMIC |