Basic Information
| LncRNA/CircRNA Name | circFOXO3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, fluorescent in situ hybridization, RNA pull-down, Dual luciferase reporter, and RNA immunoprecipitation assays |
| Sample | glioblastoma tissues |
| Expression Pattern | up-regulated |
| Function Description | CircFOXO3 expression was significantly higher in GBM tissues than in noncancerous tissues. GBM cell proliferation and invasion were reduced by circFOXO3 knockdown and enhanced by circFOXO3 overexpression. |
| Pubmed ID | 31504797 |
| Year | 2019 |
| Title | CircFOXO3 Promotes Glioblastoma Progression by Acting as a Competing Endogenous RNA for NFAT5 |
External Links
| Links for circFOXO3 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |