Basic Information
| LncRNA/CircRNA Name | circFBXW7 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, colony formation, transwell, wound-healing |
| Sample | triple-negative breast cancer tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | circFBXW7 was downregulated in TNBC cell lines and found that low expression of circFBXW7 was associated with poorer clinical outcomes. Overexpression of circFBXW7 obviously inhibited cell proliferation, migration, and tumor growth in both in vitro and in vivo assays. |
| Pubmed ID | 31536884 |
| Year | 2019 |
| Title | circFBXW7 Inhibits Malignant Progression by Sponging miR-197-3p and Encoding a 185-aa Protein in Triple-Negative Breast Cancer |
External Links
| Links for circFBXW7 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |