Basic Information
| LncRNA/CircRNA Name | CCAL |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot, in vitro knockdown |
| Sample | Human thyroid epithelium cell lines (BCPAP, FTC133, 8505C, TPC-1 and HTH-83) |
| Expression Pattern | up-regulated |
| Function Description | In mechanism, we found that knockdown of CCAL dramatically decreased the expression of NOTCH1 and suppressed the activation of NOTCH1 signaling pathway. Furthermore, Overexpression of NOTCH1 rescued the proliferation, migration and invasion in papillary thyroid cancer cells. Taken together, our data indicated that CCAL promoted papillary thyroid cancer development and progression by activation of NOTCH1 pathway, which provided a new insight on the design of therapeutic targets. |
| Pubmed ID | 29471887 |
| Year | 2018 |
| Title | Long non-coding RNA CCAL promotes papillary thyroid cancer progression by activation of NOTCH1 pathway. |
External Links
| Links for CCAL | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |