Basic Information
| LncRNA/CircRNA Name | circ_0000218 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, western blot, Dual luciferase reporter assay and RNA immunoprecipitation assay |
| Sample | colorectal cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | We demonstrated that circ_0000218 was notably upregulated in CRC tissues and cell lines, and its high expression level was markedly linked to the increase of T staging and local lymph node metastasis. Circ_0000218 overexpression enhanced the proliferation and metastasis of CRC cells while knocking down circ_0000218 caused the opposite effects. |
| Pubmed ID | 31598673 |
| Year | 2019 |
| Title | Circ_0000218 Plays a Carcinogenic Role in Colorectal Cancer Progression by Regulating miR-139-3p/RAB1A Axis |
External Links
| Links for circ_0000218 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |