Basic Information
| LncRNA/CircRNA Name | circFOXP1 |
| Synonyms | circ_0008234 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, Double luciferase reporter, RNA immunoprecipitation (RIP) and RNA pull-down assays |
| Sample | gallbladder cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | we identified that circFOXP1 (hsa_circ_0008234) expression was significantly upregulated in GBC tissues and positively associated with lymph node metastasis, advanced TNM stage and poor prognosis in patients. Short hairpin RNA mediated knockdown or exogenous expression of circFOXP1 combined with in vitro assays demonstrated that circFOXP1 has pleiotropic effects, including promotion of cell proliferation, migration, invasion, and inhibition of cell apoptosis in GBC. |
| Pubmed ID | 31623628 |
| Year | 2019 |
| Title | Circular RNA FOXP1 Promotes Tumor Progression and Warburg Effect in Gallbladder Cancer by Regulating PKLR Expression |
External Links
| Links for circFOXP1 | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |