Basic Information
| LncRNA/CircRNA Name | circAPC |
| Synonyms | circ_0127621 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Diffuse Large B-cell Lymphoma |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | Diffuse Large B-cell Lymphoma tissues, cell lines and plasma |
| Expression Pattern | down-regulated |
| Function Description | hsa_circ_0127621 was downregulated in DLBCL tissues, cell lines and plasma. In gain-of-function experiments, ectopic expression of circ-APC inhibited DLBCL cell proliferation in vitro and tumor growth in vivo. |
| Pubmed ID | 31631067 |
| Year | 2019 |
| Title | A Circular RNA From APC Inhibits the Proliferation of Diffuse Large B-cell Lymphoma by Inactivating Wnt/?-catenin Signaling via Interacting With TET1 and miR-888 |
External Links
| Links for circAPC | GenBank HGNC NONCODE |
| Links for Diffuse Large B-cell Lymphoma | OMIM COSMIC |