Basic Information
| LncRNA/CircRNA Name | circ_0001546 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Pull-down assay and Dual luciferase reporter assay |
| Sample | gastric cancer tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | Our study verified that circ_0001546 was decreased in GC and correlated with the poor prognosis. Overexpression of circ_0001546 inhibited the proliferation and chemoresistance of HGC-27 cells, and increased the expression of ATM. |
| Pubmed ID | 31668372 |
| Year | 2019 |
| Title | Hsa_circ_0001546 Acts as a miRNA-421 Sponge to Inhibit the Chemoresistance of Gastric Cancer Cells via ATM/Chk2/p53-dependent Pathway |
External Links
| Links for circ_0001546 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |