Basic Information
| LncRNA/CircRNA Name | circAKT3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blotting, RNA pull-down assay and luciferase reporter assay |
| Sample | clear cell renal cell carcinoma tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | Circ-AKT3 was verified significantly downregulated in ccRCC. Knockdown of circ-AKT3 promoted ccRCC migration and invasion, while overexpression of circ-AKT3 suppressed ccRCC metastasis. Further, circ-AKT3/miR-296-3p/E-cadherin axis was shown responsible for circ-AKT3 inhibiting ccRCC metastasis. |
| Pubmed ID | 31672157 |
| Year | 2019 |
| Title | Circ-AKT3 Inhibits Clear Cell Renal Cell Carcinoma Metastasis via Altering miR-296-3p/E-cadherin Signals |
External Links
| Links for circAKT3 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |