Basic Information
| LncRNA/CircRNA Name | circFoxo3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR and luciferase assay |
| Sample | esophageal cancer tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | In this study, circ-Foxo3 was lowly expressed in cell lines and ESCC tissues. Meanwhile, overexpression of circ-Foxo3 inhibited cell growth, migration, and invasion, whether in vivo or in vitro. Mechanically, we found a potential miRNA target, miR-23a, which negatively correlated with circ-Foxo3 in ESCC. |
| Pubmed ID | 31680314 |
| Year | 2019 |
| Title | Circular RNA circ-Foxo3 Inhibits Esophageal Squamous Cell Cancer Progression via the miR-23a/PTEN Axis |
External Links
| Links for circFoxo3 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |