Basic Information
LncRNA/CircRNA Name | circSETDB1 |
Synonyms | |
Region | |
Ensemble | |
Refseq |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | ovarian cancer |
ICD-0-3 | C56.9 |
Methods | qPCR |
Sample | ovarian cancer serum |
Expression Pattern | up-regulated |
Function Description | Serum circSETDB1 expression is upregulated in SOC patients. Higher levels of circSETDB1 are positively associated with advanced clinical stage, lymph node metastasis of SOC patients. Notably, serum circSETDB1 levels are significantly increased in primary chemoresistance patients. Patients with higher levels of circSETDB1 have a shorter progression-free survival time. |
Pubmed ID | 31686850 |
Year | 2019 |
Title | Serum circSETDB1 Is a Promising Biomarker for Predicting Response to Platinum-Taxane-Combined Chemotherapy and Relapse in High-Grade Serous Ovarian Cancer |
External Links
Links for circSETDB1 | GenBank HGNC NONCODE |
Links for ovarian cancer | OMIM COSMIC |