Basic Information
| LncRNA/CircRNA Name | circFOXP1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR |
| Sample | liver cancer tissues, serum and cell lines |
| Expression Pattern | up-regulated |
| Function Description | We found that circ-FOXP1 was significantly upregulated in HCC tissues, serum and cell lines. Depletion of circ-FOXP1 significantly inhibited HCC cell proliferation, invasion and induced apoptosis. Clinically, high circ-FOXP1 was closely correlated with larger tumor size, microvascular invasion, advanced TNM stage, and predicted poor prognosis. |
| Pubmed ID | 31698267 |
| Year | 2019 |
| Title | Circular RNA circ-FOXP1 Induced by SOX9 Promotes Hepatocellular Carcinoma Progression via Sponging miR-875-3p and miR-421 |
External Links
| Links for circFOXP1 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |