Basic Information
| LncRNA/CircRNA Name | circGSK3? |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | droplet digital PCR |
| Sample | esophageal squamous cell carcinoma tissues and plasma |
| Expression Pattern | up-regulated |
| Function Description | We demonstrated that upregulated expression of circGSK3? was positively associated with advanced clinical stage and poor outcome in patients with ESCC. We further revealed that circGSK3? promoted ESCC cell migration and invasion via direct interaction with GSK3? and inhibiting GSK3? activity, providing a novel mechanism of circRNA in cancer progression. Importantly, we identified that circGSK3? expression in plasma was a biomarker for detection of ESCC and early stage of ESCC with the area under curve (AUC) of 0.782 and 0.793, respectively. |
| Pubmed ID | 31722716 |
| Year | 2019 |
| Title | circGSK3? promotes metastasis in esophageal squamous cell carcinoma by augmenting ?-catenin signaling |
External Links
| Links for circGSK3? | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |