Basic Information
| LncRNA/CircRNA Name | circZFR |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR |
| Sample | bladder cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | the expression of circZFR was higher in bladder cancer tissues and cells compared with adjacent non-tumor tissues and normal bladder epithelial cells. And higher circZFR levels were positively correlated with bladder cancer patients' pathological T stage, grade, lymphatic metastasis, recurrence, progression-free survival (PFS) and overall survival (OS). Functionally, knockdown of circZFR could significantly prohibit cell growth, migration and invasion, arrest cell cycle as well as promote apoptosis of bladder cancer cells in vitro study. |
| Pubmed ID | 31746333 |
| Year | 2019 |
| Title | CircZFR serves as a prognostic marker to promote bladder cancer progression by regulating miR-377/ZEB2 signaling |
External Links
| Links for circZFR | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |