Basic Information
| LncRNA/CircRNA Name | circERBB2 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, CCK-8 and western blot |
| Sample | gallbladder cancer tissues |
| Expression Pattern | differential expressed |
| Function Description | CircERBB2 promotes GBC proliferation, in vitro and in vivo. Other than being a miRNA sponge, circERBB2 accumulates in the nucleoli and regulates ribosomal DNA transcription, which is one of the rate-limiting steps of ribosome synthesis and cellular proliferation. |
| Pubmed ID | 31752867 |
| Year | 2019 |
| Title | Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription |
External Links
| Links for circERBB2 | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |