Basic Information
| LncRNA/CircRNA Name | circ_0000515 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Dual luciferase reporter assay, RNA pull-down and RIP assays |
| Sample | cervical cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | hsa_circ_0000515 and ETS transcription factor ELK1 (ELK1) were initially over-expressed and miR-326 was down-regulated in cervical cancer tissues and cells. In vitro experiments exhibited that silencing of hsa_circ_0000515 or upregulation of miR-326 resulted in suppressed proliferation and invasion, along with induced apoptosis and autophagy of cervical cancer cells. Low hsa_circ_0000515 expression was found to be associated with favorable prognosis of patients with cervical cancer. |
| Pubmed ID | 31772143 |
| Year | 2019 |
| Title | Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1 |
External Links
| Links for circ_0000515 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |