Basic Information
| LncRNA/CircRNA Name | circTFCP2L1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, loss-of-function experiments |
| Sample | triple-negative breast cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | The results showed that circ-TFCP2L1 was significantly up-regulated in TNBC tissues and cells, tending to have a shorter disease-free survival of TNBC patients. In vitro loss-of-function experiments showed that knockdown of circ-TFCP2L1 significantly suppressed the proliferation and migration of TNBC cells. |
| Pubmed ID | 31776835 |
| Year | 2019 |
| Title | Circ-TFCP2L1 Promotes the Proliferation and Migration of Triple Negative Breast Cancer through Sponging miR-7 by Inhibiting PAK1 |
External Links
| Links for circTFCP2L1 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |