Basic Information
| LncRNA/CircRNA Name | circFoxo3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | urothelial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, and flow cytometry |
| Sample | urothelial cancer cell lines |
| Expression Pattern | up-regulated |
| Function Description | circ-Foxo3 was downregulated in bladder cancer in vivo and in vitro, and was upregulated in response to apoptotic stress. Overexpression of circ-Foxo3 promoted bladder cancer cell apoptosis in BBN mice and in human bladder cancer cell lines. |
| Pubmed ID | 31802888 |
| Year | 2019 |
| Title | Circular RNA circ-Foxo3 induced cell apoptosis in urothelial carcinoma via interaction with miR-191-5p |
External Links
| Links for circFoxo3 | GenBank HGNC NONCODE |
| Links for urothelial cancer | OMIM COSMIC |