Basic Information
| LncRNA/CircRNA Name | circ_0003418 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, western blot, CCK-8 assay, transwell migration assay, transwell invasion assay and drug-sensitivity analysis |
| Sample | liver cancer tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | The expression level of circ_0003418 was downregulated in HCC tissues and cell lines, and the level correlated with tumor size, TNM stage and HBsAg level in HCC patients. circ_0003418 knockdown promoted HCC cells' proliferation, migration, and invasion. Additionally, suppression of circ_0003418 enhanced cisplatin resistance of HCC cells in vivo and vitro. |
| Pubmed ID | 31807029 |
| Year | 2019 |
| Title | circ_0003418 Inhibits Tumorigenesis And Cisplatin Chemoresistance Through Wnt/?-Catenin Pathway In Hepatocellular Carcinoma |
External Links
| Links for circ_0003418 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |