Basic Information
| LncRNA/CircRNA Name | circCLK3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, pull-down, RNA immunoprecipitation (RIP), luciferase reporter and rescue assays |
| Sample | cervical cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | We found that the level of circCLK3 was remarkably higher in cervical cancer tissues than in adjacent normal tissues, and closely associated with tumor differentiation, FIGO stage and depth of stromal invasion. Down-regulated circCLK3 evidently inhibited cell growth and metastasis of cervical cancer in vitro and in vivo, while up-regulated circCLK3 significantly promoted cell growth and metastasis in vitro and in vivo. |
| Pubmed ID | 31831728 |
| Year | 2019 |
| Title | The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression |
External Links
| Links for circCLK3 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |