Basic Information
| LncRNA/CircRNA Name | CAT104 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay |
| Sample | gastric carcinoma cell line (NCI-N87, SGC7901, BGC823, BGC803 and AGS) |
| Expression Pattern | up-regulated |
| Function Description | CAT104 was highly expressed in human GC NCI-N87, SGC7901, BGC823, BGC803 and AGS cells. Suppression of CAT104 decreased NCI-N87 cell viability, migration and invasion, but promoted apoptosis. CAT104 knockdown enhanced the expression of microRNA-381 (miR-381) expression in NCI-N87 cells. miR-381 participated in the regulation effects of CAT104 on NCI-N87 cell viability, migration, invasion and apoptosis. Zinc finger E-box binding homeobox 1 (ZEB1) was identified as a direct target of miR-381. Overexpression of ZEB1 revealed the miR-381 mimicinduced cell viability, migration and invasion inhibition.Suppression of ZEB1 revealed the miR-381 inhibitor-induced activation of c-Jun N-terminal kinase pathway (JNK) and Wnt signaling pathways in NCI-N87 cells. |
| Pubmed ID | 29295724 |
| Year | 2018 |
| Title | Long non-coding RNA CAT104 promotes cell viability, migration and invasion in gastric carcinoma cells through activation of microRNA-381 inhibiting zinc finger E-box binding homeobox 1 (ZEB1) expression. |
External Links
| Links for CAT104 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |