Basic Information
| LncRNA/CircRNA Name | CASP5 |
| Synonyms | NA |
| Region | GRCh38_11:104994235-105023168 |
| Ensemble | ENSG00000137757 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma multiforme |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | glioblastoma multiforme tissues, cell lines (A172, U87MG, U251MG, T98G, U118MG and HA) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA CASP5 have been found to be up-regulated in GBM tissues compared with normal tissues in a microarray-based lncRNA profiling study.We observed that lncRNA CASP5 was highly expressed in GBM tissues and cell lines. Knockdown of CASP5 greatly inhibited GBM proliferation and resulted in G1 cell cycle arrest along with higher apoptosis ratios in vitro and in vivo, while overexpression led to the opposite phenomenon. Furthermore, the migration and invasion ability of GBM cells were significantly decreased after CASP5 down-regulation, while increased migration and invasion can be observed after CASP5 up-regulation. |
| Pubmed ID | 29715460 |
| Year | 2018 |
| Title | Long non-coding RNA CASP5 promotes the malignant phenotypes of human glioblastoma multiforme. |
External Links
| Links for CASP5 | GenBank HGNC NONCODE |
| Links for glioblastoma multiforme | OMIM COSMIC |