Basic Information
| LncRNA/CircRNA Name | circCAMK2A |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, CCK-8, wound healing, transwell assays, Luciferase reporter and biotin-labeled RNA pull-down assays |
| Sample | lung adenocarcinoma tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | Circ-CAMK2A overexpression was observed in LUAD and was closely associated with lymph node metastasis, distant metastasis, advanced clinical stage, and poor prognosis. Circ-CAMK2A silencing evidently inhibited LUAD cell migration and invasion, whereas circ-CAMK2A overexpression had an opposite effect. |
| Pubmed ID | 31889960 |
| Year | 2020 |
| Title | The novel circular RNA circ-CAMK2A enhances lung adenocarcinoma metastasis by regulating the miR-615-5p/fibronectin 1 pathway |
External Links
| Links for circCAMK2A | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |