Basic Information
| LncRNA/CircRNA Name | circCELSR1 |
| Synonyms | circ_0063809 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, CCK8 assay, colony formation assay and cell apoptosis assay, western blotting |
| Sample | ovarian cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | Compared with sensitive cell lines, circCELSR1 was also highly expressed in PTX-resistant ovarian cancer cell lines, and circCELSR1 silencing enhanced PTX-induced cytotoxicity in ovarian cancer cells. Meanwhile, the inhibition of circCELSR1 also caused ovarian cancer cell G0/G1 arrest and an increase in apoptosis. |
| Pubmed ID | 31945729 |
| Year | 2020 |
| Title | circCELSR1 (hsa_circ_0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252 |
External Links
| Links for circCELSR1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |