Basic Information
| LncRNA/CircRNA Name | CASC9? |
| Synonyms | ESCCAL-1, ESSCAL1, LINC00981, linc-JPH1 |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RNAi, RIP, other |
| Sample | glioma tissues and cell lines (SHG44, U87, U251, A172) |
| Expression Pattern | up-regulated |
| Function Description | Functional studies found that siRNA-mediated CASC9 silencing inhibited the proliferative ability, invasion in vitro, and impaired the tumour growth in vivo. Mechanical studies revealed that miR-519d both targeted the 3'-UTR of CASC9 and STAT3 mRNA, which was identified by luciferase reporter assay and RNA immunoprecipitation (RIP). Moreover, chromatin immunoprecipitation (ChIP) and luciferase reporter assay revealed that STAT3, an oncogenic transcription factor, could bind with the promoter of CASC9 and activate its transcriptional level. |
| Pubmed ID | 30270508 |
| Year | 2018 |
| Title | Long Noncoding RNA CASC9/miR-519d/STAT3 Positive Feedback Loop Facilitate the Glioma Tumourigenesis |
External Links
| Links for CASC9? | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |