Basic Information
| LncRNA/CircRNA Name | circTIMELESS |
| Synonyms | circ_0000408 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung squamous cell carcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR |
| Sample | lung squamous cell carcinoma tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | In our study, circTIMELESS was upregulated in both LUSC tissues and LUSC cells, and circTIMELESS expression was positively associated with the TNM stage. Moreover, circTIMELESS silencing markedly suppressed invasion in vitro and disrupted proliferation in vitro as well as in vivo. |
| Pubmed ID | 31960961 |
| Year | 2020 |
| Title | CircTIMELESS regulates the proliferation and invasion of lung squamous cell carcinoma cells via the miR-136-5p/ROCK1 axis |
External Links
| Links for circTIMELESS | GenBank HGNC NONCODE |
| Links for lung squamous cell carcinoma | OMIM COSMIC |