Basic Information
| LncRNA/CircRNA Name | circFAM114A2 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, FISH, luciferase reporter assay |
| Sample | bladder cancer tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | In this study, we found circFAM114A2 was significantly downregulated both in UCB tissue specimens and cell lines, and the expression level was highly correlated with pathological TNM stage and grade. Functionally, overexpression of circFAM114A2 dramatically inhibited the migration, invasion and proliferation of UCB cells in vitro, and suppressed tumor growth in vivo. |
| Pubmed ID | 31969560 |
| Year | 2020 |
| Title | Circular RNA FAM114A2 suppresses progression of bladder cancer via regulating ??P63 by sponging miR-762 |
External Links
| Links for circFAM114A2 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |