Basic Information
| LncRNA/CircRNA Name | circHUWE1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, cell proliferation assays, flow cytometry, and transwell assays |
| Sample | colorectal cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | High expression of circHUEW1 was significantly associated with lymphovascular invasion (P =0.036), lymph node metastasis (P =0.017), distant metastasis (P =0.024), and TNM stage (P =0.009). Silencing circHUWE1 significantly inhibited the proliferation, migration and invasion capacity of CRC cells in vitro. |
| Pubmed ID | 32021287 |
| Year | 2020 |
| Title | Circular RNA circHUWE1 Is Upregulated and Promotes Cell Proliferation, Migration and Invasion in Colorectal Cancer by Sponging miR-486 |
External Links
| Links for circHUWE1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |