Basic Information
| LncRNA/CircRNA Name | circCRIM1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, RNA immunoprecipitation, luciferase reporter assay, pull-down assay |
| Sample | nasopharyngeal cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | CircCRIM1 was also overexpressed in NPC tissues with distant metastasis, and its overexpression promoted NPC cell metastasis and EMT. Mechanistically, circCRIM1 competitively bound to miR-422a and prevented the suppressive effects of miR-422a on its target gene FOXQ1, which finally led to NPC metastasis, EMT and docetaxel chemoresistance. |
| Pubmed ID | 32061262 |
| Year | 2020 |
| Title | Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1 |
External Links
| Links for circCRIM1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |