Basic Information
| LncRNA/CircRNA Name | CASC9 |
| Synonyms | CASC9, ESCCAL-1, ESSCAL1, LINC00981 |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, RNAi, Cell migration and invasion assay etc. |
| Sample | ESCC tissues, cell lines (TE1, Kyse150, EC109, EC9706, and EC1) |
| Expression Pattern | up-regulated |
| Function Description | We found that the lncRNA, CASC9, was markedly upregulated in ESCC tissues. Furthermore, knockdown of CASC9 significantly suppressed cell migration and invasion in vitro. Furthermore, enhanced CASC9 expression level was correlated with differentiation. |
| Pubmed ID | 27431358 |
| Year | 2016 |
| Title | The long noncoding RNA CASC9 regulates migration and invasion in esophageal cancer. |
External Links
| Links for CASC9 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |