Basic Information
| LncRNA/CircRNA Name | circMUC16 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, FISH, western blot and immunohistochemistry |
| Sample | ovarian cancer tissues and cdll lines |
| Expression Pattern | up-regulated |
| Function Description | CircMUC16 had increased expression in EOC tissues as compared to healthy ovarian tissues. Hence, silencing circMUC16 suppressed autophagy flux of SKOV3 cells. CircMUC16-mediated autophagy exacerbated EOC invasion and metastasis. |
| Pubmed ID | 32111227 |
| Year | 2020 |
| Title | CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a |
External Links
| Links for circMUC16 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |