Basic Information
| LncRNA/CircRNA Name | CASC9 |
| Synonyms | CASC9, ESCCAL-1, ESSCAL1, LINC00981 |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | Microarray, qPCR, RNAi, MTT assay etc. |
| Sample | cell lines (SW1990, BxPC etc.) |
| Expression Pattern | up-regulated |
| Function Description | We selected two upregulated lncRNAs (LINC00152 and CASC9) that were reported to be upregulated in other cancers, and two mostly downregulated lncRNAs (LINC00226 and F11-AS1) for further validation in PDAC cell lines and the normal cell line HPDE. CASC9 and LINC00152 were overexpressed in most of the PDAC cell lines compared with HPDE cells. Knockdown of LINC00152 and CASC9 impaired PDAC cells proliferation and invasion. |
| Pubmed ID | 28220683 |
| Year | 2017 |
| Title | Analysis of distinct long noncoding RNA transcriptional fingerprints in pancreatic ductal adenocarcinoma. |
External Links
| Links for CASC9 | GenBank HGNC NONCODE |
| Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |