Detail

Basic Information

LncRNA/CircRNA Name	circFOXM1
Synonyms
Region
Ensemble
Refseq

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	melanoma
ICD-0-3	NA
Methods	qPCR, RIP
Sample	melanoma tissues and cell lines
Expression Pattern	down-regulated
Function Description	Circ-FOXM1 was elevated and miR-143-3p was reduced in melanoma tissues and cells. Circ-FOXM1 deficiency impeded cell proliferation, invasion, and glycolysis and facilitated cell apoptosis in melanoma in vitro and tumorigenesis in vivo. Circ-FOXM1 acted as a sponge of miR-143-3p and the impacts of circ-FOXM1 silencing on cell proliferation, apoptosis, invasion, and glycolysis were overturned by miR-143-3p deletion.
Pubmed ID	32183822
Year	2020
Title	Circ-FOXM1 contributes to cell proliferation, invasion, and glycolysis and represses apoptosis in melanoma by regulating miR-143-3p/FLOT2 axis

External Links

Links for circFOXM1	GenBank HGNC NONCODE
Links for melanoma	OMIM COSMIC