Basic Information
| LncRNA/CircRNA Name | circ_0004390 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR |
| Sample | ovarian cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | Circ0004390, which was frequently upregulated in ovarian cancer tissues. The knockdown of Circ0004390 can significantly reduce the proliferation of ovarian cancer cells. We further demonstrated that Circ0004390 may promote cell proliferation by acting as a sponge for the miR-198 family to regulated the MET expression in ovarian cancer cells. The level of Circ0004390 was closely related with overall survival of ovarian cancer patients. |
| Pubmed ID | 32192774 |
| Year | 2020 |
| Title | Circ0004390 promotes cell proliferation through sponging miR-198 in ovarian cancer |
External Links
| Links for circ_0004390 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |