Basic Information
| LncRNA/CircRNA Name | circCDYL |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNA immunoprecipitation, circRNAs pull-down, Dual luciferase report assay, Western blot, Immunofluorescence and Immunohistochemical staining |
| Sample | breast cancer tissues and serum |
| Expression Pattern | up-regulated |
| Function Description | An autophagy associated circRNA circCDYL was elevated by 3.2 folds in BC tissues as compared with the adjacent non-cancerous tissues, and circCDYL promoted autophagic level in BC cells via the miR-1275-ATG7/ULK1 axis; Clinically, increased circCDYL in the tumor tissues and serum of BC patients was associated with higher tumor burden, shorter survival and poorer clinical response to therapy. |
| Pubmed ID | 32213200 |
| Year | 2020 |
| Title | Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression |
External Links
| Links for circCDYL | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |