Basic Information
| LncRNA/CircRNA Name | CASC9 |
| Synonyms | NA |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP |
| Sample | Human normal gastric epithelial cell line GES-1 and GC cell lines (SGC7901 and MKN-45), GC tissues and paired adjacent tissues |
| Expression Pattern | up-regulated |
| Function Description | LncRNA CASC9 was upregulated in GC tissue and GC cells, and high CASC9 expression was positively correlated with TNM stage and lymph node metastasis. Silencing CASC9 promoted the apoptosis of GC cells. LncRNA CASC9 could interact with BMI1 and positively regulate BMI1 expression. Silencing CASC9 promoted the ubiquitination of BMI1. In addition, lncRNA CASC9 regulated the apoptosis of GC cells through BMI1. Furthermore, interfering CASC9 inhibited the tumor growth of GC. |
| Pubmed ID | 31642035 |
| Year | 2019 |
| Title | LncRNA CASC9 Suppressed the Apoptosis of Gastric Cancer Cells through Regulating BMI1 |
External Links
| Links for CASC9 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |