Basic Information
| LncRNA/CircRNA Name | circ_0079662 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blotting, Dual luciferase assay, miRNA pull-down assay, coimmunoprecipitation and ELASA |
| Sample | colon cell lines |
| Expression Pattern | up-regulated |
| Function Description | The results showed that the expression of hsa_circ_0079662 was increased in drug-resistant cell lines by RT-PCR. In conclusion, hsa_circ_0079662, as a ceRNA binding with hsa-mir-324-5p, can regulate target gene HOXA9 and induced the mechanism of chemotherapy drug oxaliplatin resistance in CRC through the TNF-? pathway in human colon cancer. |
| Pubmed ID | 32243061 |
| Year | 2020 |
| Title | Hsa_circ_0079662 induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF-? pathway in human colon cancer |
External Links
| Links for circ_0079662 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |