Basic Information
| LncRNA/CircRNA Name | circRGNEF |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | EdU, CCK8, colony formation and Transwell assays |
| Sample | bladder cancer tissue and cell lines |
| Expression Pattern | up-regulated |
| Function Description | Expression profile analysis of human circRNAs in BC revealed that circRGNEF was upregulated significantly. High circRGNEF expression was correlated with aggressive BC phenotypes. The downregulation of circRGNEF suppressed BC cell metastasis and proliferation by targeting the miR-548/KIF2C axis in vitro and in vivo |
| Pubmed ID | 32305958 |
| Year | 2020 |
| Title | Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation |
External Links
| Links for circRGNEF | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |