Basic Information
| LncRNA/CircRNA Name | CASC9 |
| Synonyms | NA |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | RIP, Western blot , RT-qPCR etc. |
| Sample | cervical cancer cell lines (HeLa, SiHa, C-33A and CaSki) and human normal cervix epithelial cells (CerEpiC) |
| Expression Pattern | down-regulated |
| Function Description | CASC9 expression was markedly increased in cervical cancer tissues and cell lines. Cervical cancer patients with low CASC9 expression showed better overall survival rate.Moreover, cancer-associated fibroblasts (CAFs)-derived transforming growth factor ? (TGF-?) could increase CASC9 expression. The crosslink between CAFs and cervical cancer cells led to CASC9 to elevate the metastasis of cervical cancer cells. CASC9 dysregulation could function as a miRNA sponge to competitively protect twist homolog 2 (TWIST2) mRNA 3'UTR from miR-215. |
| Pubmed ID | 31178137 |
| Year | 2019 |
| Title | Long Non-Coding RNA CASC9 Enhances Breast Cancer Progression by Promoting Metastasis Through the Meditation of miR-215/TWIST2 Signaling Associated With TGF-? Expression |
External Links
| Links for CASC9 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |