Basic Information
| LncRNA/CircRNA Name | CASC9 |
| Synonyms | NA |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Western blot , RIP , RNA-seq , in vitro knockdown etc. |
| Sample | Human CRC cell lines (HCT-116, HCT-116 p53???? SW620, SW480, HT-29, LoVo, LS-174T),RKO,HEK293T cells,fresh primary colorectal tumors and matched adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | CASC9 was frequently upregulated in CRC, which was correlated with advanced TNM stage, and higher CASC9 levels were associated with poor patient outcomes.Knockdown of CASC9 inhibited growth and promoted apoptosis in CRC cells, whereas ectopic CASC9 expression promoted cell growth in vitro and in vivo.CASC9 exerts its oncogenic activity by modulating TGF?2 mRNA stability and upregulating the levels of TGF?2 and TERT, resulting in an increase in phosphorylated SMAD3 and activation of TGF-? signaling, and enhanced TERT complex function in CRC cells. |
| Pubmed ID | 31186036 |
| Year | 2019 |
| Title | LncRNA CASC9 Interacts With CPSF3 to Regulate TGF-? Signaling in Colorectal Cancer |
External Links
| Links for CASC9 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |